Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling

Disruption of hepatocyte growth hormone (GH) signaling through disruption of Jak2 (JAK2L) leads to fatty liver. Previously, we demonstrated that development of fatty liver depends on adipocyte GH signaling. We sought to determine the individual roles of hepatocyte and adipocyte Jak2 on whole-body an...

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Udgivet i:Diabetes
Main Authors: Corbit, Kevin C., Camporez, João Paulo G., Edmunds, Lia R., Tran, Jennifer L., Vera, Nicholas B., Erion, Derek M., Deo, Rahul C., Perry, Rachel J., Shulman, Gerald I., Jurczak, Michael J., Weiss, Ethan J.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2018
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780061/
https://ncbi.nlm.nih.gov/pubmed/29203511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0524
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