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High-fat diet–induced vagal afferent dysfunction via upregulation of 2-pore domain potassium TRESK channel

Research shows that rats and humans on a high-fat diet (HFD) are less sensitive to satiety signals known to act via vagal afferent pathways. We hypothesize that HFD causes an upregulation of 2-pore domain potassium channels, resulting in hyperpolarization of nodose ganglia (NG) and decreased vagal r...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Grabauskas, Gintautas, Wu, Xiaoyin, Zhou, ShiYi, Li, JiYao, Gao, Jun, Owyang, Chung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777907/
https://ncbi.nlm.nih.gov/pubmed/31484832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130402
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