Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells

`NK cell–mediated regulation of antigen-specific T cells can contribute to and exacerbate chronic viral infection, but the protective mechanisms against NK cell–mediated attack on T cell immunity are poorly understood. Here, we show that progranulin (PGRN) can reduce NK cell cytotoxicity through red...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Huang, Anfei, Shinde, Prashant V., Huang, Jun, Senff, Tina, Xu, Haifeng C., Margotta, Cassandra, Häussinger, Dieter, Willnow, Thomas E., Zhang, Jinping, Pandyra, Aleksandra A., Timm, Jörg, Weggen, Sascha, Lang, Karl S., Lang, Philipp A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777906/
https://ncbi.nlm.nih.gov/pubmed/31484831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129856
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