Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells

`NK cell–mediated regulation of antigen-specific T cells can contribute to and exacerbate chronic viral infection, but the protective mechanisms against NK cell–mediated attack on T cell immunity are poorly understood. Here, we show that progranulin (PGRN) can reduce NK cell cytotoxicity through red...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Huang, Anfei, Shinde, Prashant V., Huang, Jun, Senff, Tina, Xu, Haifeng C., Margotta, Cassandra, Häussinger, Dieter, Willnow, Thomas E., Zhang, Jinping, Pandyra, Aleksandra A., Timm, Jörg, Weggen, Sascha, Lang, Karl S., Lang, Philipp A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777906/
https://ncbi.nlm.nih.gov/pubmed/31484831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129856
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