PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation

Dysregulation of polycomb repressive complex 2 (PRC2) promotes oncogenesis partly through its enzymatic function for inducing trimethylation of histone H3 lysine 27 (H3K27me3). However, it remains to be determined how PRC2 activity is regulated in normal and diseased settings. We here report a PRC2-...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Ren, Zhihong, Ahn, Jeong Hyun, Liu, Hequn, Tsai, Yi-Hsuan, Bhanu, Natarajan V., Koss, Brian, Allison, David F., Ma, Anqi, Storey, Aaron J., Wang, Ping, Mackintosh, Samuel G., Edmondson, Ricky D., Groen, Richard W. J., Martens, Anton C., Garcia, Benjamin A., Tackett, Alan J., Jin, Jian, Cai, Ling, Zheng, Deyou, Wang, Gang Greg
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776795/
https://ncbi.nlm.nih.gov/pubmed/31383640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000578
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