PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation

Dysregulation of polycomb repressive complex 2 (PRC2) promotes oncogenesis partly through its enzymatic function for inducing trimethylation of histone H3 lysine 27 (H3K27me3). However, it remains to be determined how PRC2 activity is regulated in normal and diseased settings. We here report a PRC2-...

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Bibliografski detalji
Izdano u:Blood
Glavni autori: Ren, Zhihong, Ahn, Jeong Hyun, Liu, Hequn, Tsai, Yi-Hsuan, Bhanu, Natarajan V., Koss, Brian, Allison, David F., Ma, Anqi, Storey, Aaron J., Wang, Ping, Mackintosh, Samuel G., Edmondson, Ricky D., Groen, Richard W. J., Martens, Anton C., Garcia, Benjamin A., Tackett, Alan J., Jin, Jian, Cai, Ling, Zheng, Deyou, Wang, Gang Greg
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2019
Teme:
Lymphoid Neoplasia
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776795/
https://ncbi.nlm.nih.gov/pubmed/31383640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000578
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