PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation

Dysregulation of polycomb repressive complex 2 (PRC2) promotes oncogenesis partly through its enzymatic function for inducing trimethylation of histone H3 lysine 27 (H3K27me3). However, it remains to be determined how PRC2 activity is regulated in normal and diseased settings. We here report a PRC2-...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ren, Zhihong, Ahn, Jeong Hyun, Liu, Hequn, Tsai, Yi-Hsuan, Bhanu, Natarajan V., Koss, Brian, Allison, David F., Ma, Anqi, Storey, Aaron J., Wang, Ping, Mackintosh, Samuel G., Edmondson, Ricky D., Groen, Richard W. J., Martens, Anton C., Garcia, Benjamin A., Tackett, Alan J., Jin, Jian, Cai, Ling, Zheng, Deyou, Wang, Gang Greg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776795/
https://ncbi.nlm.nih.gov/pubmed/31383640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000578
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