North- and South-Bicyclo[3.1.0] Hexene Nucleosides. The Effect of Ring Planarity on Anti-HIV Activity

The syntheses of new conformationally locked North and South bicyclo[3.1.0]hexene nucleosides is reported. The North analogues were synthesized by a convergent approach from the known (1S,2R,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]bicyclo[3.1.0]hex-3-en-2-ol (7) via Mitsunobu coupling with the nuc...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Russ, Pamela L., Gonzalez-Moa, Maria J., Vu, B. Christie, Sigano, Dina M., Kelley, James A., Lai, Christopher C., Deschamps, Jeffrey R., Hughes, Stephen H., Marquez, Victor E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776084/
https://ncbi.nlm.nih.gov/pubmed/19533724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900153
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