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Conformational Insights into the Mechanism of Acetylaminofluorene-dG-Induced Frameshift Mutations in the Narl Mutational Hotspot
Frameshift mutagenesis encompasses the gain or loss of DNA base pairs, resulting in altered genetic outcomes. The NarI restriction site sequence 5′-G(1)G(2)CG(3)CX-3′ in Escherichia coli is a well-known mutational hotspot, in which lesioning of acetylaminofluorene (AAF) at G(3)* induces a greater −2...
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| Publié dans: | Chem Res Toxicol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6775635/ https://ncbi.nlm.nih.gov/pubmed/26733364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00484 |
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