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Conformational Insights into the Mechanism of Acetylaminofluorene-dG-Induced Frameshift Mutations in the Narl Mutational Hotspot

Frameshift mutagenesis encompasses the gain or loss of DNA base pairs, resulting in altered genetic outcomes. The NarI restriction site sequence 5′-G(1)G(2)CG(3)CX-3′ in Escherichia coli is a well-known mutational hotspot, in which lesioning of acetylaminofluorene (AAF) at G(3)* induces a greater −2...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Xu, Lifang, Cho, Bongsup P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775635/
https://ncbi.nlm.nih.gov/pubmed/26733364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00484
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