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Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro

Human norovirus (HuNoV) is the main cause of gastroenteritis worldwide, yet no therapeutics are currently available. Here, we utilize a human norovirus replicon in human gastric tumor (HGT) cells to identify host factors involved in promoting or inhibiting HuNoV replication. We observed that an inte...

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Pubblicato in:mBio
Autori principali: Arthur, Sabastine E., Sorgeloos, Frédéric, Hosmillo, Myra, Goodfellow, Ian G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775457/
https://ncbi.nlm.nih.gov/pubmed/31575769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02155-19
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