Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses

Human noroviruses (HuNoV) are a leading cause of viral gastroenteritis worldwide and a significant cause of morbidity and mortality in all age groups. The recent finding that HuNoV can be propagated in B cells and mucosa-derived intestinal epithelial organoids (IEOs) has transformed our ability to d...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Hosmillo, Myra, Chaudhry, Yasmin, Nayak, Komal, Sorgeloos, Frederic, Koo, Bon-Kyoung, Merenda, Alessandra, Lillestol, Reidun, Drumright, Lydia, Zilbauer, Matthias, Goodfellow, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078467/
https://ncbi.nlm.nih.gov/pubmed/32184238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00215-20
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