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Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro

Human norovirus (HuNoV) is the main cause of gastroenteritis worldwide, yet no therapeutics are currently available. Here, we utilize a human norovirus replicon in human gastric tumor (HGT) cells to identify host factors involved in promoting or inhibiting HuNoV replication. We observed that an inte...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Arthur, Sabastine E., Sorgeloos, Frédéric, Hosmillo, Myra, Goodfellow, Ian G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775457/
https://ncbi.nlm.nih.gov/pubmed/31575769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02155-19
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