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HILPDA regulates lipid metabolism, lipid droplet abundance, and response to microenvironmental stress in solid tumors.

Accumulation of lipid droplets has been observed in an increasing range of tumors. However, the molecular determinants of this phenotype and the impact of the tumor microenvironment on lipid droplet dynamics are not well defined. The hypoxia-inducible and lipid droplet associated protein HILPDA is k...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: VandeKopple, Matthew J., Wu, Jinghai, Auer, Erich N., Giaccia, Amato J., Denko, Nicholas C., Papandreou, Ioanna
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774878/
https://ncbi.nlm.nih.gov/pubmed/31308147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1343
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