Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism

Tumor hypoxia reduces the effectiveness of radiation therapy by limiting the biologically effective dose. An acute increase in tumor oxygenation before radiation treatment should therefore significantly improve the tumor cell kill after radiation. Efforts to increase oxygen delivery to the tumor hav...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Benej, Martin, Hong, Xiangqian, Vibhute, Sandip, Scott, Sabina, Wu, Jinghai, Graves, Edward, Le, Quynh-Thu, Koong, Albert C., Giaccia, Amato J., Yu, Bing, Chen, Ching-Shih, Papandreou, Ioanna, Denko, Nicholas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196495/
https://ncbi.nlm.nih.gov/pubmed/30201710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808945115
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