Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism

Tumor hypoxia reduces the effectiveness of radiation therapy by limiting the biologically effective dose. An acute increase in tumor oxygenation before radiation treatment should therefore significantly improve the tumor cell kill after radiation. Efforts to increase oxygen delivery to the tumor hav...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Benej, Martin, Hong, Xiangqian, Vibhute, Sandip, Scott, Sabina, Wu, Jinghai, Graves, Edward, Le, Quynh-Thu, Koong, Albert C., Giaccia, Amato J., Yu, Bing, Chen, Ching-Shih, Papandreou, Ioanna, Denko, Nicholas C.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196495/
https://ncbi.nlm.nih.gov/pubmed/30201710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808945115
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