Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism

Tumor hypoxia reduces the effectiveness of radiation therapy by limiting the biologically effective dose. An acute increase in tumor oxygenation before radiation treatment should therefore significantly improve the tumor cell kill after radiation. Efforts to increase oxygen delivery to the tumor hav...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Benej, Martin, Hong, Xiangqian, Vibhute, Sandip, Scott, Sabina, Wu, Jinghai, Graves, Edward, Le, Quynh-Thu, Koong, Albert C., Giaccia, Amato J., Yu, Bing, Chen, Ching-Shih, Papandreou, Ioanna, Denko, Nicholas C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196495/
https://ncbi.nlm.nih.gov/pubmed/30201710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808945115
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