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Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy
Solid tumors frequently contain large regions with low oxygen concentrations (hypoxia). The hypoxic microenvironment induces adaptive changes to tumor cell metabolism, and this alteration can further distort the local microenvironment. The net result of these tumor-specific changes is a microenviron...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1890514/ https://ncbi.nlm.nih.gov/pubmed/17517659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611662104 |
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