A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity

Prior work indicates DEPTOR expression in multiple myeloma (MM) cells could be a therapeutic target. DEPTOR binds to mTOR via its PDZ domain and inhibits mTOR kinase activity. We previously identified a drug, which prevented mTOR-DEPTOR binding (NSC126405) and induced MM cytotoxicity. We now report...

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Pubblicato in:Mol Cancer Ther
Autori principali: Vega, Mario I., Shi, Yijiang, Frost, Patrick, Huerta-Yepez, Sara, Antonio-Andres, Gabriela, Hernandez-Pando, Rogelio, Lee, Jihye, Jung, Michael E., Gera, Joseph F., Lichtenstein, Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774835/
https://ncbi.nlm.nih.gov/pubmed/31395691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0115
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