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Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease

Filament formation by enzymes is increasingly recognized as an important phenomenon with potentially unique regulatory properties and biological roles. SgrAI is an allosterically regulated type II restriction endonuclease that forms filaments with enhanced DNA cleavage activity and altered sequence...

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Dades bibliogràfiques
Publicat a:Structure
Autors principals: Polley, Smarajit, Lyumkis, Dmitry, Horton, Nancy C.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774820/
https://ncbi.nlm.nih.gov/pubmed/31447289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.08.001
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