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New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA

SgrAI is a type II restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self-activation with expansion of DNA-sequence specificity. The three-dimensional crystal structures of SgrAI bound to cleaved primary-site DNA and Mg(2+) and bound to secondary-site...

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Detalhes bibliográficos
Main Authors: Little, Elizabeth J., Dunten, Pete W., Bitinaite, Jurate, Horton, Nancy C.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016018/
https://ncbi.nlm.nih.gov/pubmed/21206063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910047785
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