The structure of SgrAI bound to DNA; recognition of an 8 base pair target

The three-dimensional X-ray crystal structure of the ‘rare cutting’ type II restriction endonuclease SgrAI bound to cognate DNA is presented. SgrAI forms a dimer bound to one duplex of DNA. Two Ca(2+) bind in the enzyme active site, with one ion at the interface between the protein and DNA, and the...

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Autores principales: Dunten, Pete W., Little, Elizabeth J., Gregory, Mark T., Manohar, Veena M., Dalton, Michael, Hough, David, Bitinaite, Jurate, Horton, Nancy C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532715/
https://ncbi.nlm.nih.gov/pubmed/18701646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn510
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