The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models

A requirement for Mouse Double Minute 2 (MDM2) oncogene activation has been suggested to be associated with cancer progression and metastasis, including breast cancer. To date, most MDM2 inhibitors have been designed to block the MDM2–p53-binding interphase, and have low or no efficacy against advan...

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發表在:Nat Commun
Main Authors: Wang, Wei, Qin, Jiang-Jiang, Voruganti, Sukesh, Srivenugopal, Kalkunte S., Nag, Subhasree, Patil, Shivaputra, Sharma, Horrick, Wang, Ming-Hai, Wang, Hui, Buolamwini, John K., Zhang, Ruiwen
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774205/
https://ncbi.nlm.nih.gov/pubmed/25271708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6086
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