Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice

BACKGROUND & AIMS: The oncogene MDM2, which encodes an E3 ubiquitin ligase, is overexpressed in pancreatic cancers and is therefore a therapeutic target. Current inhibitors of MDM2 target the interaction between MDM2 and P53; these would have no effect on cancer cells that do not express full-le...

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Bibliografiske detaljer
Main Authors: WANG, WEI, QIN, JIANG-JIANG, VORUGANTI, SUKESH, WANG, MING-HAI, SHARMA, HORRICK, PATIL, SHIVAPUTRA, ZHOU, JIANWEI, WANG, HUI, MUKHOPADHYAY, DEBABRATA, BUOLAMWINI, JOHN K., ZHANG, RUIWEN
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170027/
https://ncbi.nlm.nih.gov/pubmed/25016295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.07.001
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