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Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation

The MDM2 oncogene has been suggested as a molecular target for treating human cancers, including breast cancer. Most MDM2 inhibitors under development are targeting the MDM2-p53 binding, and have little or no effects on cancers without functional p53, such as advanced breast cancer. The present stud...

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Foilsithe in:Oncotarget
Main Authors: Qin, Jiang-Jiang, Wang, Wei, Voruganti, Sukesh, Wang, Hui, Zhang, Wei-Dong, Zhang, Ruiwen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413606/
https://ncbi.nlm.nih.gov/pubmed/25739118
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