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Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy
The transcription factor NFAT1 and the oncogene MDM2 have crucial roles in breast cancer development, progression, and metastasis. We have recently discovered that NFAT1 activates MDM2 expression. Here, we identified a small molecule (named Inulanolide A) that dually inhibited both NFAT1 and MDM2 in...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5078034/ https://ncbi.nlm.nih.gov/pubmed/27105525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8873 |
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