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Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy

The transcription factor NFAT1 and the oncogene MDM2 have crucial roles in breast cancer development, progression, and metastasis. We have recently discovered that NFAT1 activates MDM2 expression. Here, we identified a small molecule (named Inulanolide A) that dually inhibited both NFAT1 and MDM2 in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Qin, Jiang-Jiang, Wang, Wei, Sarkar, Sushanta, Voruganti, Sukesh, Agarwal, Rajesh, Zhang, Ruiwen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078034/
https://ncbi.nlm.nih.gov/pubmed/27105525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8873
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