Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice

There is an increasing interest in targeting the MDM2 oncogene for cancer therapy. SP-141, a novel designed small molecule MDM2 inhibitor, exerts excellent in vitro and in vivo anticancer activity. To facilitate the preclinical development of this candidate anticancer agent, we have developed an HPL...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biomed Chromatogr
Prif Awduron: Nag, Subhasree, Qin, Jiang-Jiang, Voruganti, Sukesh, Wang, Ming-Hai, Sharma, Horrick, Patil, Shivaputra, Buolamwini, John K., Wang, Wei, Zhang, Ruiwen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710169/
https://ncbi.nlm.nih.gov/pubmed/25294254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.3327
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg