The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an essential role in protecting cell viability through modulation of oxidative stress. TRPM2 is highly expressed in cancer. When TRPM2 is inhibited, mitochondria are dysfunctional, ROS levels are increased, and cell viabi...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Bao, Lei, Festa, Fernanda, Freet, Christopher S., Lee, John P., Hirschler-Laszkiewicz, Iwona M., Chen, Shu-jen, Keefer, Kerry A., Wang, Hong-Gang, Patterson, Andrew D., Cheung, Joseph Y., Miller, Barbara A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773863/
https://ncbi.nlm.nih.gov/pubmed/31575956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50661-8
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