The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an essential role in protecting cell viability through modulation of oxidative stress. TRPM2 is highly expressed in cancer. When TRPM2 is inhibited, mitochondria are dysfunctional, ROS levels are increased, and cell viabi...

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Vydáno v:Sci Rep
Hlavní autoři: Bao, Lei, Festa, Fernanda, Freet, Christopher S., Lee, John P., Hirschler-Laszkiewicz, Iwona M., Chen, Shu-jen, Keefer, Kerry A., Wang, Hong-Gang, Patterson, Andrew D., Cheung, Joseph Y., Miller, Barbara A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773863/
https://ncbi.nlm.nih.gov/pubmed/31575956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50661-8
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