The Transient Receptor Potential (TRP) Channel TRPC3 TRP Domain and AMP-activated Protein Kinase Binding Site Are Required for TRPC3 Activation by Erythropoietin

Modulation of intracellular calcium ([Ca(2+)](i)) by erythropoietin (Epo) is an important signaling pathway controlling erythroid proliferation and differentiation. Transient receptor potential (TRP) channels TRPC3 and homologous TRPC6 are expressed on normal human erythroid precursors, but Epo stim...

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Autores principales: Hirschler-Laszkiewicz, Iwona, Tong, Qin, Waybill, Kathleen, Conrad, Kathleen, Keefer, Kerry, Zhang, Wenyi, Chen, Shu-jen, Cheung, Joseph Y., Miller, Barbara A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162424/
https://ncbi.nlm.nih.gov/pubmed/21757714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238360
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