Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in maintaining cell survival following oxidant injury. Here, we show that TRPM2 is highly expressed in acute myeloid leukemia (AML). The role of TRPM2 in AML was studied following depletion with CRISPR/Cas9 techn...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chen, Shu-jen, Bao, Lei, Keefer, Kerry, Shanmughapriya, Santhanam, Chen, Longgui, Lee, John, Wang, JuFang, Zhang, Xue-Qian, Hirschler-Laszkiewicz, Iwona, Merali, Salim, Merali, Carmen, Imamura, Yuka, Dovat, Sinisa, Madesh, Muniswamy, Cheung, Joseph Y., Wang, Hong-Gang, Miller, Barbara A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170900/
https://ncbi.nlm.nih.gov/pubmed/32312983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2454-8
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