A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α

The calcium-permeable ion channel TRPM2 is highly expressed in a number of cancers. In neuroblastoma, full-length TRPM2 (TRPM2-L) protected cells from moderate oxidative stress through increased levels of forkhead box transcription factor 3a (FOXO3a) and superoxide dismutase 2. Cells expressing the...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Chen, Shu-jen, Hoffman, Nicholas E., Shanmughapriya, Santhanam, Bao, Lei, Keefer, Kerry, Conrad, Kathleen, Merali, Salim, Takahashi, Yoshinori, Abraham, Thomas, Hirschler-Laszkiewicz, Iwona, Wang, JuFang, Zhang, Xue-Qian, Song, Jianliang, Barrero, Carlos, Shi, Yuguang, Kawasawa, Yuka Imamura, Bayerl, Michael, Sun, Tianyu, Barbour, Mustafa, Wang, Hong-Gang, Madesh, Muniswamy, Cheung, Joseph Y., Miller, Barbara A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276889/
https://ncbi.nlm.nih.gov/pubmed/25391657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620922
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