Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics

Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in modulating cell survival following oxidant injury and is highly expressed in many cancers including neuroblastoma. Here, in xenografts generated from neuroblastoma cells in which TRPM2 was depleted with CRISPR...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bao, Lei, Chen, Shu-jen, Conrad, Kathleen, Keefer, Kerry, Abraham, Thomas, Lee, John P., Wang, JuFang, Zhang, Xue-Qian, Hirschler-Laszkiewicz, Iwona, Wang, Hong-Gang, Dovat, Sinisa, Gans, Brian, Madesh, Muniswamy, Cheung, Joseph Y., Miller, Barbara A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114400/
https://ncbi.nlm.nih.gov/pubmed/27694440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.747147
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