MRGPRX4 is a bile acid receptor for human cholestatic itch

Patients with liver diseases often suffer from chronic itch, yet the pruritogen(s) and receptor(s) remain largely elusive. Here, we identify bile acids as natural ligands for MRGPRX4. MRGPRX4 is expressed in human dorsal root ganglion (hDRG) neurons and co-expresses with itch receptor HRH1. Bile aci...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Yu, Huasheng, Zhao, Tianjun, Liu, Simin, Wu, Qinxue, Johnson, Omar, Wu, Zhaofa, Zhuang, Zihao, Shi, Yaocheng, Peng, Luxin, He, Renxi, Yang, Yong, Sun, Jianjun, Wang, Xiaoqun, Xu, Haifeng, Zeng, Zheng, Zou, Peng, Lei, Xiaoguang, Luo, Wenqin, Li, Yulong
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2019
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773440/
https://ncbi.nlm.nih.gov/pubmed/31500698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48431
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires