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Bile Acids Reach Out to the Spinal Cord: New Insights to the Pathogenesis of Itch and Analgesia in Cholestatic Liver Disease
Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which are elevated in the circulation and tissues during cholestasis, cause itch and analgesia by activating the GPCR TGR5. TGR5 was detected in pept...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3966955/ https://ncbi.nlm.nih.gov/pubmed/24532150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26786 |
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