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MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus
Patients suffering from cholestasis, the slowing or stoppage of bile flow, commonly report experiencing an intense, chronic itch. Numerous pruritogens are up-regulated in cholestatic patient sera, including bile acids (BAs). Acute injection of BAs results in itch in both mice and humans, and BA-modu...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6535009/ https://ncbi.nlm.nih.gov/pubmed/31068464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903316116 |
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