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MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus
Patients suffering from cholestasis, the slowing or stoppage of bile flow, commonly report experiencing an intense, chronic itch. Numerous pruritogens are up-regulated in cholestatic patient sera, including bile acids (BAs). Acute injection of BAs results in itch in both mice and humans, and BA-modu...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6535009/ https://ncbi.nlm.nih.gov/pubmed/31068464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903316116 |
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