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MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus

Patients suffering from cholestasis, the slowing or stoppage of bile flow, commonly report experiencing an intense, chronic itch. Numerous pruritogens are up-regulated in cholestatic patient sera, including bile acids (BAs). Acute injection of BAs results in itch in both mice and humans, and BA-modu...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Meixiong, James, Vasavda, Chirag, Snyder, Solomon H., Dong, Xinzhong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535009/
https://ncbi.nlm.nih.gov/pubmed/31068464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903316116
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