JAK3 inhibitor-based immunosuppression in allogeneic islet transplantation in cynomolgus monkeys

Islet transplantation is efficacious to prevent severe hypoglycemia and glycemic liability of selected patients of type 1 diabetes. However, since calcineurin inhibitor (CNI) causes β-cell and nephrotoxicity, alternative drug(s) with similar potency and safety profile to CNI will be highly desirable...

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Published in:Islets
Main Authors: Kim, Jong-Min, Shin, Jun-Seop, Min, Byoung-Hoon, Kang, Seong-Jun, Yoon, Il-Hee, Chung, Hyunwoo, Kim, Jiyeon, Hwang, Eung-Soo, Ha, Jongwon, Park, Chung-Gyu
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773385/
https://ncbi.nlm.nih.gov/pubmed/31483188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19382014.2019.1650580
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