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Neurodegeneration in Lurcher Mice Occurs via Multiple Cell Death Pathways
Lurcher (Lc) is a gain-of-function mutation in the δ2 glutamate receptor (GRID2) that results in the cell-autonomous death of cerebellar Purkinje cells in heterozygouslurcher (+/Lc) mice. This in turn triggers the massive loss of afferent granule cells during the first few postnatal weeks. Evidence...
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| Gepubliceerd in: | J Neurosci |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Society for Neuroscience
2000
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6772704/ https://ncbi.nlm.nih.gov/pubmed/10804210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-10-03687.2000 |
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