Reevaluation of Neurodegeneration in lurcher Mice: Constitutive Ion Fluxes Cause Cell Death with, Not by, Autophagy

The lurcher (Lc) mice have served as a valuable model for neurodegeneration for decades. Although the responsible mutation was identified in genes encoding δ2 glutamate receptors (GluD2s), which are predominantly expressed in cerebellar Purkinje cells, how the mutant receptor (GluD2(Lc)) triggers ce...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Nishiyama, Jun, Matsuda, Keiko, Kakegawa, Wataru, Yamada, Nobuaki, Motohashi, Junko, Mizushima, Noboru, Yuzaki, Michisuke
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2010
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6634053/
https://ncbi.nlm.nih.gov/pubmed/20147545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6030-09.2010
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