Pregnenolone Sulfate Modulates Inhibitory Synaptic Transmission by Enhancing GABA(A) Receptor Desensitization

We examined the effects of the neurosteroid pregnenolone sulfate (PS) on GABA(A) receptor-mediated synaptic currents and currents elicited by rapid applications of GABA onto nucleated outside-out patches in cultured postnatal rat hippocampal neurons. At 10 μm, PS significantly depressed peak respons...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Shen, Weixing, Mennerick, Steven, Covey, Douglas F., Zorumski, Charles F.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2000
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ARTICLE
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772674/
https://ncbi.nlm.nih.gov/pubmed/10804198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-10-03571.2000
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