Mice Deficient in the Polysialyltransferase ST8SiaIV/PST-1 Allow Discrimination of the Roles of Neural Cell Adhesion Molecule Protein and Polysialic Acid in Neural Development and Synaptic Plasticity

Functional properties of the neural cell adhesion molecule (NCAM) are strongly influenced by polysialylation. We used gene-targeting to generate mice lacking ST8SiaIV/PST-1, one of the polysialyltransferases responsible for addition of polysialic acid (PSA) to NCAM. Mice homozygous for the null muta...

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發表在:J Neurosci
Main Authors: Eckhardt, Matthias, Bukalo, Olena, Chazal, Geneviève, Wang, Lihua, Goridis, Christo, Schachner, Melitta, Gerardy-Schahn, Rita, Cremer, Harold, Dityatev, Alexander
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772332/
https://ncbi.nlm.nih.gov/pubmed/10884307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-14-05234.2000
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