Mice Deficient in the Polysialyltransferase ST8SiaIV/PST-1 Allow Discrimination of the Roles of Neural Cell Adhesion Molecule Protein and Polysialic Acid in Neural Development and Synaptic Plasticity

Functional properties of the neural cell adhesion molecule (NCAM) are strongly influenced by polysialylation. We used gene-targeting to generate mice lacking ST8SiaIV/PST-1, one of the polysialyltransferases responsible for addition of polysialic acid (PSA) to NCAM. Mice homozygous for the null muta...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Eckhardt, Matthias, Bukalo, Olena, Chazal, Geneviève, Wang, Lihua, Goridis, Christo, Schachner, Melitta, Gerardy-Schahn, Rita, Cremer, Harold, Dityatev, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772332/
https://ncbi.nlm.nih.gov/pubmed/10884307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-14-05234.2000
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