Dysfunctions in Mice by NMDA Receptor Point Mutations NR1(N598Q) and NR1(N598R)

NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutatedNR1 alleles, NR1(Q/Q) andNR1(−/R) mice, developed a perinatally lethal phenotype mainly characterized by r...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Single, Frank N., Rozov, Andrei, Burnashev, Nail, Zimmermann, Frank, Hanley, Daniel F., Forrest, Douglas, Curran, Tom, Jensen, Vidar, Hvalby, Øivind, Sprengel, Rolf, Seeburg, Peter H.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772252/
https://ncbi.nlm.nih.gov/pubmed/10729336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-07-02558.2000
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