Phenotypic Knockout of Nerve Growth Factor in Adult Transgenic Mice Reveals Severe Deficits in Basal Forebrain Cholinergic Neurons, Cell Death in the Spleen, and Skeletal Muscle Dystrophy

The disruption of the nerve growth factor (NGF) gene in transgenic mice leads to a lethal phenotype (Crowley et al., 1994) and hinders the study of NGF functions in the adult. In this study the phenotypic knockout of NGF in adult mice was achieved by expressing transgenic anti-NGF antibodies, under...

Full description

Saved in:
Bibliographic Details
Published in:J Neurosci
Main Authors: Ruberti, Francesca, Capsoni, Simona, Comparini, Alessandro, Di Daniel, Elena, Franzot, Jessica, Gonfloni, Stefania, Rossi, Gabriella, Berardi, Nicoletta, Cattaneo, Antonino
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2000
Subjects:
ARTICLE
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772248/
https://ncbi.nlm.nih.gov/pubmed/10729339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-07-02589.2000
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items