Phenotypic Knockout of Nerve Growth Factor in Adult Transgenic Mice Reveals Severe Deficits in Basal Forebrain Cholinergic Neurons, Cell Death in the Spleen, and Skeletal Muscle Dystrophy

The disruption of the nerve growth factor (NGF) gene in transgenic mice leads to a lethal phenotype (Crowley et al., 1994) and hinders the study of NGF functions in the adult. In this study the phenotypic knockout of NGF in adult mice was achieved by expressing transgenic anti-NGF antibodies, under...

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Bibliografiset tiedot
Julkaisussa:J Neurosci
Päätekijät: Ruberti, Francesca, Capsoni, Simona, Comparini, Alessandro, Di Daniel, Elena, Franzot, Jessica, Gonfloni, Stefania, Rossi, Gabriella, Berardi, Nicoletta, Cattaneo, Antonino
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2000
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ARTICLE
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772248/
https://ncbi.nlm.nih.gov/pubmed/10729339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-07-02589.2000
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