Phenotypic Knockout of Nerve Growth Factor in Adult Transgenic Mice Reveals Severe Deficits in Basal Forebrain Cholinergic Neurons, Cell Death in the Spleen, and Skeletal Muscle Dystrophy

The disruption of the nerve growth factor (NGF) gene in transgenic mice leads to a lethal phenotype (Crowley et al., 1994) and hinders the study of NGF functions in the adult. In this study the phenotypic knockout of NGF in adult mice was achieved by expressing transgenic anti-NGF antibodies, under...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ruberti, Francesca, Capsoni, Simona, Comparini, Alessandro, Di Daniel, Elena, Franzot, Jessica, Gonfloni, Stefania, Rossi, Gabriella, Berardi, Nicoletta, Cattaneo, Antonino
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
Assuntos:
ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772248/
https://ncbi.nlm.nih.gov/pubmed/10729339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-07-02589.2000
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