(19)F NMR Monitoring of Reversible Protein Post‐Translational Modifications: Class D β‐Lactamase Carbamylation and Inhibition

Bacterial production of β‐lactamases with carbapenemase activity is a global health threat. The active sites of class D carbapenemases such as OXA‐48, which is of major clinical importance, uniquely contain a carbamylated lysine residue which is essential for catalysis. Although there is significant...

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Bibliographische Detailangaben
Veröffentlicht in:Chemistry
Hauptverfasser: van Groesen, Emma, Lohans, Christopher T., Brem, Jürgen, Aertker, Kristina M. J., Claridge, Timothy D. W., Schofield, Christopher J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771976/
https://ncbi.nlm.nih.gov/pubmed/31310409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902529
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