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Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid

OBJECTIVE: Oligomeric forms of amyloid β protein (oAβ) are believed to be principally responsible for neurotoxicity in Alzheimer disease (AD), but it is not known whether anti‐Aβ antibodies are capable of lowering oAβ levels in humans. METHODS: We developed an ultrasensitive immunoassay and used it...

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書目詳細資料
發表在:Ann Neurol
Main Authors: Yang, Ting, Dang, Yifan, Ostaszewski, Beth, Mengel, David, Steffen, Verena, Rabe, Christina, Bittner, Tobias, Walsh, Dominic M., Selkoe, Dennis J.
格式: Artigo
語言:Inglês
出版: John Wiley & Sons, Inc. 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771589/
https://ncbi.nlm.nih.gov/pubmed/31168802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25513
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