Recovering gene interactions from single-cell data using data diffusion

Single-cell RNA-sequencing technologies suffer from many sources of technical noise, including under-sampling of mRNA molecules, often termed ‘dropout’, which can severely obscure important gene-gene relationships. To address this, we developed MAGIC (Markov Affinity-based Graph Imputation of Cells)...

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Veröffentlicht in:Cell
Hauptverfasser: van Dijk, David, Sharma, Roshan, Nainys, Juozas, Yim, Kristina, Kathail, Pooja, Carr, Ambrose, Burdziak, Cassandra, Moon, Kevin R., Chaffer, Christine L., Pattabiraman, Diwakar, Bierie, Brian, Mazutis, Linas, Wolf, Guy, Krishnaswamy, Smita, Pe’er, Dana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771278/
https://ncbi.nlm.nih.gov/pubmed/29961576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.05.061
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