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Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration

Mutations in the Abelson-helper integration site 1 (AHI1) gene are associated with neurological/neuropsychiatric disorders, and cause the neurodevelopmental ciliopathy Joubert syndrome (JBTS). Here, we show that deletion of the transition zone (TZ) protein Ahi1 in mouse embryonic fibroblasts (MEFs)...

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Detalles Bibliográficos
Publicado en:J Cell Sci
Autores principales: Muñoz-Estrada, Jesús, Ferland, Russell J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771145/
https://ncbi.nlm.nih.gov/pubmed/31391239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.230680
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