Interstitial Flow Recapitulates Gemcitabine Chemoresistance in A 3D Microfluidic Pancreatic Ductal Adenocarcinoma Model by Induction of Multidrug Resistance Proteins

Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal cancers due to a high chemoresistance and poor vascularization, which results in an ineffective systemic therapy. PDAC is characterized by a high intratumoral pressure, which is not captured by current 2D and 3D in vitro models. Here,...

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Detaylı Bibliyografya
Yayımlandı:Int J Mol Sci
Asıl Yazarlar: Kramer, Bart, de Haan, Luuk, Vermeer, Marjolein, Olivier, Thomas, Hankemeier, Thomas, Vulto, Paul, Joore, Jos, Lanz, Henriëtte L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770899/
https://ncbi.nlm.nih.gov/pubmed/31546820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20184647
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