ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Gemcitabine, as a single agent or in combination therapy, remains the frontline chemotherapy despite its limited efficacy due to de novo or acquired chemoresistance. There is an acute need to decipher mechanis...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Chakraborty, Asmi, Dorsett, Kaitlyn A., Trummell, Hoa Q., Yang, Eddy S., Oliver, Patsy G., Bonner, James A., Buchsbaum, Donald J., Bellis, Susan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777269/
https://ncbi.nlm.nih.gov/pubmed/29191829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808584
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